Exploring Metal-Organic Framework-Coated Blades for Direct and High-Throughput Screening Analysis of Complex Biological Matrices.

ABSTRACT: Ambient ionization mass spectrometry (AIMS) techniques have become an emerging approach over the last years due to their simplicity, permitting high-throughput sample analysis by directly coupling with mass spectrometry while ensuring short analysis times. Among AIMS techniques, coated-blade spray (CBS) has stood out, as it ensures a significant enhancement of overall sensitivity, undoubtedly useful for human biofluid analysis. In parallel, the incorporation of advanced smart materials, such as metal-organic frameworks (MOFs), into analytical devices is increasing due to their outstanding ability to efficiently trap target analytes, such as industrial chemicals with diverse functionalities and polarities. This study integrates neat MOFs in CBS devices, without the need for any composite or

SUBMITTER: Negrin-Santamaria I 

PROVIDER: S-EPMC12409693 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature