Urinary tobacco and nicotine exposure biomarkers as predictors of transitions between cigarette and e-cigarette use in the Exhale longitudinal cohort study.

ABSTRACT:

Introduction

Urinary tobacco and nicotine exposure biomarkers may be predictive of subsequent transitions in product use.

Methods

We used data from an observational study of 371 adults who smoked cigarettes daily, some of whom also used e-cigarettes, and who were followed every two months for up to two years (Wisconsin, US, 2015-19). Using a multistate transition model, we assessed continuous associations between transition propensities and urinary tobacco biomarker concentrations, namely 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol) (NNAL) and NE-2 (cotinine + trans-3'-hydroxycotinine), the nicotine metabolite ratio (NMR; trans-3'-hydroxycotinine:cotinine), and NNAL:NE-2, measured every 4 months.

Results

The biomarkers were generally more predictive of transitions f

SUBMITTER: Brouwer AF 

PROVIDER: S-EPMC12409742 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature