Brain Reward System Dysfunction in Adolescence: Current, Cumulative, and Developmental Periods of Depression.

ABSTRACT:

Objective

Reward system dysfunction is a well-known correlate and predictor of depression in adults and adolescents, with depressed individuals showing blunted (hyporeactive) striatal response to monetary rewards. Furthermore, studies of remitted depression suggest network-wide hyporeactivity of striatal (caudate, putamen, nucleus accumbens) and cortical (insula, anterior cingulate cortex [ACC]) regions even in the absence of current symptoms. Thus, it remains unclear which patterns of hyporeactivity represent a trait-like indicator of depression and which represent a current depressed state. The authors examined the relationships between regions of a cortico-striatal circuit supporting reward processing and both current depression and cumulative depression history.

Methods

SUBMITTER: Rappaport BI 

PROVIDER: S-EPMC12409776 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature