Bioassay-guided isolation of terpenoids from the soft coral <i>Sclerophytum humesi</i> and assessment of their antidiabetic and cytotoxic activities.

ABSTRACT: This study represents the first report on the secondary metabolites from the soft coral Sclerophytum humesi. Nine terpenoids (1-9) were isolated by antidiabetic-guided isolation, including a new xeniaphyllane-type diterpenoid (Sclerohumin O, 1) and a new norcaryophyllene-type sesquiterpenoid (Norsclerohumin P, 6). These compounds feature a distinctive 4/9-fused ring system, which was the first isolated in the Sclerophytum genus. All compounds were subjected to evaluation for their antidiabetic and cytotoxic activities. Notably, compound 1 demonstrated substantial inhibitory activity against key metabolic enzymes implicated in diabetes, namely α-amylase, α-glucosidase, and lipase, with IC₅₀ values of 100.3 ± 1.02, 170.0 ± 0.92, and 16.1 ± 2.15 μM, respectively. More

SUBMITTER: Luu PV 

PROVIDER: S-EPMC12409781 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature