Ibuprofen-Functionalized Alkyl α-hydroxy Methacrylate-Based Polymers.

ABSTRACT: Novel alkyl α-hydroxymethacrylate-based prodrugs are prepared to improve bioavailability, decrease toxicity, and control drug release. First, an ibuprofen (IBU)-functionalized methacrylate (TBMA-IBU) is synthesized from the reaction of tert-butyl α-bromomethacrylate with IBU. The free radical homopolymerization and copolymerization with poly(ethylene glycol) methyl ether methacrylate (M_n = 300), cleavage of tert-butyl ester groups of the homopolymer and a copolymer with trifluoroacetic acid (TFA) gave new polymer prodrugs (p-TBMA-IBU, p-TBMA-IBU-co-PEGMA, p-MA-IBU, and p-MA-IBU-co-PEGMA), with IBU linked through ester bonds on the side chain. The release studies showed extended-release of IBU (20-60% in 15 d), which can be triggered under the stimulation of lipase. The in vitro

SUBMITTER: Balaban B 

PROVIDER: S-EPMC12409833 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature