The predictive value of tacrolimus intrapatient variability and time in therapeutic range for renal transplant outcomes.

ABSTRACT:

Background

Tacrolimus is key in renal transplantation. This study evaluated optimal intrapatient variability (IPV) and time in therapeutic range (TTR) thresholds and association with renal outcomes.

Methods

This single-center study (1999-2018) had a mean follow-up of 3 years. All patients received tacrolimus-based immunosuppression, and excluded those switching from cyclosporin. Receiver operating characteristic curves evaluated IPV and TTR cutoff values for biopsy-proved acute rejection (BPAR). Cox regression, Chi-square, Mann-Whitney U, Kaplan-Meier, and log-rank tests were used for outcome analysis.

Results

The cohort included 463 patients (mean age 47.3 years; 44.1% female). Most received cadaveric grafts (66.4%) and ABO-compatible transplants (97.4%). Pree

SUBMITTER: Cheng CY 

PROVIDER: S-EPMC12409856 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature