Emerging <i>Clostridioides difficile</i> strains belonging to PCR ribotype 955 in Serbia are distinct from metronidazole-resistant RT955 outbreak isolates from the UK.

ABSTRACT: End 2023, the UK Health Security Agency sent an alert about a new hypervirulent Clostridioides difficile PCR ribotype, ribotype 955 (RT955), causing slowly progressing infection clusters in hospitals in the Midlands. Between March 2018 and February 2022, surveillance of Clostridioides difficile infections (CDI) was performed in southern Serbia with centres providing medical services for approximately 750,000 inhabitants. Using the ECDC recommended protocol, clinical, epidemiological and microbiological data were collected. C. difficile RT955 was identified in 27 (7%) of 383 surveyed patients with CDI. Of 27 patients, 16 (59%) was older than 60 years and 19 (70%) were male. CDI was always associated with previous antibiotic therapy and had a hospital onset in 23 (85%) p

SUBMITTER: Stojanovic P 

PROVIDER: S-EPMC12409861 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature