Triptolide improves microbial dysbiosis and metabolite disorder in db/db mice.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is an increasing global public health problem. Triptolide (TP) has a good therapeutic effect on DKD and is widely used in China. However, the mechanism of TP is still unclear.

Methods

Db/db mice models were subjected to TP for 12 weeks. UHPLC-QE-MS and 16S rRNA amplicon sequencing were used to investigate the correlations between the metabolome, microbiome, and DKD-related indicators under DKD condition.

Results

TP demonstrated significant nephroprotective effects in db/db mice, ameliorated renal functional impairment and structural damage while attenuated inflammatory responses associated with DKD. Notably, TP administration effectively restored gut microbiota dysbiosis in db/db mice. Comparative analysis identified ten altere

SUBMITTER: Lu L 

PROVIDER: S-EPMC12409871 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature