Integrated multi-tissue transcriptomics reveals cross-tissue regulatory networks and hub genes regulating feed efficiency in aging chicken.

ABSTRACT: Given the critical impact of feed costs on poultry profitability, it is essential to improve feed efficiency through genetic selection. Although residual feed intake (RFI) serves as the gold-standard metric for feed efficiency assessment, its molecular regulation remains poorly understood. This study estimated the residual feed intake of laying hens from 70 to 100 weeks of age (E-RFI) and estimated the genetic parameters of key production traits (egg quality and feed efficiency) and lipid traits (triglycerides: TG; free fatty acids: FFA; cholesterol: TC). By decoupling the genetic covariance with production traits, we selected 40 extreme E-RFI individuals and performed multiple aspects of transcriptomic analysis across seven tissues (hypothalamus, pituitary, liver, pancreas, duodenum, ileu

SUBMITTER: Han Y 

PROVIDER: S-EPMC12410010 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature