Umbilical cord blood-derived exosomes deliver miR-182-5p to Therapeutically target the MYD88/NF-κB signaling pathway in rat peri-implantitis.

ABSTRACT: Peri-implantitis (PI) is a major cause of implant restoration failure, necessitating therapeutic strategies that integrate bone regeneration and anti-inflammatory effects. Despite advances in treatment, no existing agents simultaneously address both objectives. Exosomes (Exos), as key mediators of intercellular communication, have demonstrated dual anti-inflammatory and osteogenic capacities through microRNA (miRNA) delivery; however, their potential in PI therapy remains unexplored. This study evaluates the therapeutic efficacy of a composite hydrogel loaded with human umbilical cord blood-derived exosomes (UCB-Exos) in PI treatment, focusing on its dual anti-inflammatory and bone-regenerative functions, and elucidates the underlying molecular mechanisms. In vitro experiments revea

SUBMITTER: Liu H 

PROVIDER: S-EPMC12410187 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature