Nkx3.2 Inhibits Retinal Degeneration by Modulating Inflammation and Cell Death in RPE.

ABSTRACT:

Purpose

To identify the expression of Nkx3.2 in retinal pigment epithelium (RPE) and evaluate its physiological role in association with retinal degeneration.

Methods

Nkx3.2 expression in RPE was examined by biochemical and histological analyses. Various in vitro and in vivo assays were employed to reveal the molecular mechanisms by which Nkx3.2 regulates inflammatory responses and cell survival in RPE. In addition, by investigating multiple animal models, the biological significance of Nkx3.2 in retinal degeneration was assessed.

Results

Nkx3.2 expression was verified in human cadaveric and mouse eye tissues and shown to be regulated by aging and oxidative stress. Mouse model analyses demonstrated retina protection activity of Nkx3.2 against aging, oxidative stress,

SUBMITTER: Park M 

PROVIDER: S-EPMC12410249 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature