Association of Plasma Omega-3 Fatty Acids With POAG.

ABSTRACT:

Purpose

To investigate the association between plasma levels of omega-3 fatty acids and the risk of POAG.

Methods

We conducted prospective cohort analyses among 254,157 participants of European descent in the UK Biobank cohort. Mendelian randomization analyses were further performed to assess the causal relationship between omega-3 fatty acids and POAG using publicly available genome-wide association study summary statistics.

Results

Over 13.84 years of follow-up, 1,166 patients (0.46%) developed POAG. After adjustment for covariates including POAG polygenetic risk scores, a 1-unit (mmol/L) increment in plasma levels of omega-3 polyunsaturated fatty acids was significantly associated with a decreased risk of incident POAG (hazard ratio, 0.61; 95% confidence interval,

SUBMITTER: Kai JY 

PROVIDER: S-EPMC12410257 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature