Sustained Benefit of Short-Term Levodopa Treatment on Inner Retinal Function in Patients With Diabetes.

ABSTRACT:

Purpose

This study investigated the long-term progression of oscillatory potential (OP) implicit times (ITs) in individuals with preclinical diabetic retinopathy (DR) with and without levodopa (L-DOPA) treatment by quantifying functional and structural retinal changes.

Methods

Participants from the Motz et al. (2020) study were re-evaluated after 5 years, including individuals with diabetes mellitus (DM) who received L-DOPA treatment for 2 weeks (the DM + L-DOPA group; n = 14), those who did not (the DM group; n = 6), and non-diabetic healthy controls (the control group; n = 37). Retinal function and structure were assessed using dim-flash electroretinography (ERG) and optical coherence tomography (OCT).

Results

After 5 years, OP 1 and OP 2 ITs showed no significant d

SUBMITTER: Moore F 

PROVIDER: S-EPMC12410260 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature