Multi-scale simulation of red blood cell trauma in large-scale high-shear flows after Norwood operation.

ABSTRACT:

Background and objective

Cardiovascular surgeries and mechanical circulatory support devices create non-physiological blood flow conditions that can be detrimental, especially for pediatric patients. A source of complications is mechanical red blood cell (RBC) damage induced by localized supraphysiological shear fields. To understand such complications in single ventricle patients, we introduce a multi-scale numerical model to predict hemolysis risk in idealized anatomies.

Methods

We employed our in-house CFD solver coupled with Lagrangian tracking and cell-resolved fluid-structure interaction to measure flow-induced stresses and strains on the RBC membrane. The Norwood procedure, known for its high mortality rate, is selected for its importance to single-ventricle populatio

SUBMITTER: Mansour S 

PROVIDER: S-EPMC12410365 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature