Birth weight, cardiovascular health, and the risk of cardiovascular disease: A longitudinal perspective from the UK biobank cohort.

ABSTRACT:

Background

The associations between birth weight (BW), cardiovascular health (CVH) as assessed by Life's Essential 8 (LE8) and cardiovascular diseases (CVDs) remain unclear. We aimed to assess the independent and joint associations of BW and CVH with risks of CVDs.

Methods

This study included 143,910 UK Biobank participants without CVD at baseline (2006-2010). BW was self-reported, and CVH was evaluated using the LE8 score. Cox models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident total CVD and nine cardiovascular conditions.

Results

During a median 15.1-year follow-up, 24,071 CVD cases occurred. Compared with normal BW (2.5-4.0 kg), low BW was associated with increased risks of total CVD (adjusted HR [aHR]: 1.13, 95% CI

SUBMITTER: Long J 

PROVIDER: S-EPMC12410404 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature