TREM-1 as a novel immunotherapeutic target to treat pancreatic ductal adenocarcinoma.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is highly aggressive with limited curative options, primarily surgical resection. However, only about 20% of the tumors are resectable at diagnosis. Immunotherapies have largely failed in PDAC due to its immunosuppressive tumor microenvironment (TME). This study explores the potential of triggering receptor expressed on myeloid cells 1 (TREM-1) activation in altering the TME and enhancing tumor immunity in PDAC. Using the Pan02 mouse model and single-cell RNA sequencing (scRNA-seq), we found that intra-tumoral TREM-1 activation significantly reduced Pan02 tumor growth, an effect absent in Trem1 ^-/- mice. Our findings indicate that TREM-1 activation shifts tumor-associated macrophages (TAMs

SUBMITTER: Gross L 

PROVIDER: S-EPMC12410479 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature