Long-term clinical outcomes in adult congenital aortic stenosis: results from a national study.

ABSTRACT:

Background

Previous research on congenital aortic stenosis (AS) mainly focused on children, while data on long-term outcomes in adults is scarce. Therefore, this study aims to evaluate outcomes in adult patients with congenital AS and identify prognostic markers for aortic valve replacement (AVR).

Methods

In this multicentre study, patients aged 18-55 years with congenital AS (peak velocity ≥2.5 m/s) registered in the Dutch CONCOR (Congential Cor Vitia) registry from expert centres for congenital heart disease between 2001 and 2019 were included. Exclusion criteria were severe aortic regurgitation (AR) or prior AVR. Associations with the composite endpoint of all-cause mortality and AVR were assessed with multivariable Cox regression.

Results

Of the 427 included patie

SUBMITTER: Keuning ZA 

PROVIDER: S-EPMC12410621 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature