Causal association between different types of ametropia and risk of diabetic retinopathy: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

To investigate the causal link between ametropia and diabetic retinopathy, as well as to offer genetic support for the association between these two conditions.

Methods

This study employed a methodology involving the utilisation of genome-wide association studies data that are publicly accessible. Specifically, single nucleotide polymorphisms (SNPs) that exhibit a strong association with ametropia were employed as instrumental variables, and a two-sample Mendelian randomization (MR) approach was employed to examine the causal relationship between different types of ametropia and diabetic retinopathy. The main findings were derived from the utilisation of inverse variance weighted (IVW), while supplementary results were obtained through the utilisation of MR Egger,

SUBMITTER: Ma Q 

PROVIDER: S-EPMC12410644 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature