Behavioral investigation of reactive and neoplastic lymphocytes in human lymph nodes in 4D.

ABSTRACT: This study deals with a 4D investigation of lymphocytes in human tissue under reactive and neoplastic conditions. The immune system's response to pathogens highly depends on cell interaction and movement, which makes it essential to analyze these dynamics. To achieve this, we observed cells and their movement in 4D. Human lymphoid tissue was examined, including 8 cases with 23 movies of hyperplastic tissue from the pharyngeal tonsil and 12 cases with 35 movies of lymphadenitis. Additionally, there were 4 cases involving 16 movies of marginal zone lymphoma (MZL), 3 cases with 19 movies of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), 3 cases with 6 movies of follicular lymphoma grade 1/2 (FL), and 2 cases with 10 movies of diffuse large B-cell lymphoma (DLBCL). We tracked the mov

SUBMITTER: Theil DE 

PROVIDER: S-EPMC12410774 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature