Effects of s-ketamine and midazolam on respiratory variability: A randomized controlled pilot trial.

ABSTRACT: S-ketamine and midazolam are frequently used to provide sedation while maintaining spontaneous respiration. However, the effects of these agents on respiratory variability, which reflects the adaptability of the respiratory system, have not been thoroughly explored. We evaluated these effects in a randomized controlled pilot trial. This study was conducted as part of a randomized controlled trial originally designed to assess the effects of s-ketamine conditioning on pain sensitivity in patients with fibromyalgia syndrome. Participants were randomly assigned to receive an infusion of either s-ketamine (0.3 mg kg-1 h-1), midazolam (0.05 mg kg-1 h-1), or saline in a blinded fashion. Mean respiratory rate, variability of respiratory rate (VRR), and variability of tidal volume (VTV) were measu

SUBMITTER: van den Bosch OFC 

PROVIDER: S-EPMC12410786 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature