Palladium-catalyzed dearomative 1,4-hydroamination.

ABSTRACT: A dearomative 1,4-hydroamination of nonactivated arenes has been developed, using a key arene-arenophile photocycloaddition strategy to disrupt aromaticity. Palladium catalysis with K-Selectride^® as a hydride source uniquely enables selective reactivity and provides access to a range of substituted 1,4-cyclohexadienes from aromatic starting materials. We demonstrate a few synthetic applications of this scalable procedure by preparing highly-functionalized small molecules in three to four steps from naphthalene.

SUBMITTER: Gilbert R 

PROVIDER: S-EPMC12410825 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature