Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration.

ABSTRACT: JOURNAL/nrgr/04.03/01300535-202604000-00041/figure1/v/2025-06-30T060627Z/r/image-tiff Contrary to the adult central nervous system, the peripheral nervous system has an intrinsic ability to regenerate that relies on the expression of regeneration-associated genes, such as some kinesin family members. Kinesins contribute to nerve regeneration through the transport of specific cargo, such as proteins and membrane components, from the cell body towards the axon periphery. We show here that KIF4A, associated with neurodevelopmental disorders and previously believed to be only expressed during development, is also expressed in the adult vertebrate nervous system and up-regulated in injured peripheral nervous system cells. KIF4A is detected both in the cell bodies and regrowing axons of injured

SUBMITTER: Correia PD 

PROVIDER: S-EPMC12410863 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature