Efficacy of biomarkers in the endochondral phase of fracture repair and healing in long bones: A clinical observational studys.

ABSTRACT:

Background

Clinical determination of bone fracture healing remains qualitative, typically determined through the combination of plain film radiographs, clinical assessment, and patient-reported pain. Importantly, standard radiographs can only detect bone formation in the fracture site after sufficient tissue mineralization has occurred, restricting utility to the later stages of bone repair. A more rigorous method for determining fracture healing progression could significantly improve patient care. Quantitative biomarkers have gained diagnostic value in many clinical indications. Multiple bone turnover biomarkers have been successfully utilized for diagnosis and clinical management of osteoporosis. However, there remains limited evidence for the correlation and diagnostic efficacy

SUBMITTER: Working ZM 

PROVIDER: S-EPMC12410876 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature