Peripheral nerve injury mediated by JEV strain NX1889 infection and impairment of Schwann cells.

ABSTRACT: Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus primarily associated with central nervous system disorders. Recent studies have indicated that JEV infection can lead to Guillain-Barré syndrome (GBS), a peripheral nervous system (PNS) disorder; however, the underlying mechanisms remain unclear. In this study, we investigated the tropism of different genotypes of JEV strains for peripheral nerves and their potential impact on peripheral nerves. Four JEV strains-GI NX1889, GI GZ56, GIII P3, and GV XZ0934-representing three prevalent genotypes in China were selected for analysis. Compared with other JEV strains, NX1889 exhibited greater peripheral nerve tropism, leading to peripheral nerve dysfunction, severe pathological changes, and inflammatory responses. Further investigat

SUBMITTER: Yang L 

PROVIDER: S-EPMC12410878 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature