Half-Dose versus Full Dose of Aprotinin in Cardiac Surgery: A Post-hoc Analysis of the Aprotinin European Registry.

ABSTRACT:

Objectives

To compare the effectiveness and safety of the full and half doses of aprotinin, using the extended version of the Nordic Aprotinin Patient Registry, which was imposed by the European Medicines Agency following the reintroduction of aprotinin in cardiac surgery in the European market.

Methods

A post-hoc analysis was performed on data prospectively collected from adult patients exposed to aprotinin during cardiac surgery, in 83 cardiovascular surgical centres in 9 European countries, from February 26, 2016 to October 5, 2022. Full-dose (FD) and half-dose (HD) regimens were used at the surgical team's discretion. The FD loading, priming, and infusion doses were 2 MKIU, 2 MKIU, and 0.5 MKIU/h, respectively. Incidence of re-exploration for bleeding/tamponade 2 days af

SUBMITTER: Colson PH 

PROVIDER: S-EPMC12410929 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature