Pathotype-Specific Expression of Granzyme-Perforin Pathway Genes and Their Association With Clinical Disease Activity in Early Rheumatoid Arthritis and in a Randomized Clinical Trial.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease. We examined gene expression of five granzymes (GZMs), perforin (PRF-1), and serglycin (SRGN) from tissues derived from pathobiology of early arthritis cohort (PEAC) and phase 4 randomized controlled trial in anti-TNF inadequate responder patients with RA (R4RA). Information regarding gene expression of GZMs, PRF-1, and SRGN in synovium and blood pathotypes and their correlations with disease activity scores with 28 joints (DAS28)-erythrocyte sedimentation rate and with DAS28-C-reactive protein in early RA (eRA) is lacking. To determine the expression of these genes in synovium and blood pathotypes, we analyzed bulk RNA-sequencing data. The percentage of CD8+ T cells was determined in synovium, and the presence of P

SUBMITTER: La Rosa FG 

PROVIDER: S-EPMC12411107 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature