U-shaped relationship between the triglyceride glucose index and the risk of incident diabetes among MASLD adults: a retrospective cohort study.

ABSTRACT:

Background

Previous research has indicated that the triglyceride glucose index (TyG-i) may serve as a potential risk factor for type 2 diabetes (T2D). However, there is a paucity of studies addressing the relationship between TyG-i and T2D, specifically in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Consequently, this longitudinal study aims to investigate the association between TyG-i and the onset of T2D in a cohort of Japanese adults with MASLD.

Methods

This retrospective cohort study included a total of 2,507 subjects diagnosed with MASLD. To evaluate the association between the TyG-i and the risk of developing T2D, Cox proportional hazards regression models were employed to estimate hazard ratios (HR) along with 95% confidence interva

SUBMITTER: Cao C 

PROVIDER: S-EPMC12411149 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature