Role of Meox1 in promoting lung tumor vascularization and impairing CD8⁺ T cell mediated immunity.

ABSTRACT:

Introduction

Endothelial cells play a critical role in tumor-associated vasculature formation and immune modulation, and dysregulation of transcription factors (TFs) such as Meox1 has been associated with various cancers, including non-small cell lung cancer (NSCLC). Meox1 has been implicated in promoting both tumor-promoting and immune-suppressing functions.

Methods

In this study, to systematically map TF dynamics across cancer and immune cells, we performed scRNA-seq on tumor tissues and used the SCENIC framework for regulon analysis, revealing cell-type-specific gene regulatory networks. We investigated the functional role of Meox1 in NSCLC by employing a siRNA-based knockdown approach to selectively reduce its expression.

Results

Our preliminary findings reveal th

SUBMITTER: Yang D 

PROVIDER: S-EPMC12411202 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature