Chemotherapy-induced alterations in miRNA expression and their prognostic implications in ovarian cancer.

ABSTRACT:

Introduction

Ovarian cancer has a high mortality rate due to late diagnosis, relapse and chemoresistance. miRNAs play a major role in tumorigenesis as well as chemoresistance. Hence, we undertook a study, to evaluate the differential expression of miRNAs in clinical specimens of ovarian cancer patients that may highlight the effect of chemotherapy and their role in predicting survival outcomes.

Methods

Clinical specimens were collected from n=127 participants comprising chemo-naive, chemo-treated ovarian cancer patients and healthy women as controls for the study. miRNA expression was evaluated by quantitative real-time PCR analysis.

Results

Our results indicate an upregulation of miR-182 and miR-130a in the serum of treated ovarian cancer patients, which may be an ef

SUBMITTER: Ranmale S 

PROVIDER: S-EPMC12411204 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature