Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity.

ABSTRACT:

Background

Many children suffer from lingering symptoms after COVID-19, known as long COVID syndrome (LCS), otherwise called Post COVID-19 Condition (PCC). Despite extensive research, the prevalence of symptoms, its impact on quality of life, and underlying mechanisms still need to be fully understood. As neutrophilic granulocytes play an essential role in COVID-19, and their prolonged disruption was found to cause immunological diseases, we hypothesized their ongoing disturbed functionality in LCS.

Methods

We studied 129 children with LCS, 32 convalescent children (CG+), and 8 uninfected children (CG-). Online questionnaires and in-person examinations assessed symptoms, quality of life, and functioning (QoL-F). Effector functions of neutrophilic granulocytes obtained from t

SUBMITTER: Kovacs F 

PROVIDER: S-EPMC12411219 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature