Comparative analysis of plasma BNP and NT-proBNP levels, and NT-proBNP/BNP ratio in patients with chronic kidney disease.

ABSTRACT: Both B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are clinically used for diagnosing and monitoring heart failure. However, their levels are influenced by several factors, and their impacts on chronic kidney disease (CKD) patients remain unclear. This study included 1036 patients who visited the Nephrology division at our hospital between 2014 and 2015. Plasma BNP, NT-proBNP levels and the BNP/NT-proBNP ratio were measured at each CKD stage, and their correlation with clinical factors were analyzed. This study included 1037 patients with stage 1 to stage 5D CKD (CKD 1-2, n = 114; CKD 3, n = 256; CKD 4, n = 266; CKD 5, n = 298; CKD 5D, n = 102). Levels of plasma BNP and NT-proBNP levels and the NT-proBNP/BNP ratio increased, and the correlation

SUBMITTER: Fujii H 

PROVIDER: S-EPMC12411222 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature