Association between urinary sodium-to-potassium ratio and BNP in a general population without antihypertensive treatment and cardiovascular diseases: the Ohasama study.

ABSTRACT: The urinary sodium-to-potassium (Na/K) ratio is associated with blood pressure (BP) and cardiovascular risk. We examined the association between the urinary Na/K ratio and brain natriuretic peptide (BNP), a biomarker indicative of cardiac stress levels within the general population. This cross-sectional study included 436 participants (mean age: 65.4 ± 6.9 years; 73.2% women) without antihypertensive medications or cardiovascular diseases (including atrial fibrillation) from the Ohasama Study. The urinary Na/K ratio was calculated using casual daytime spot urine samples. Analyses of covariance and multiple linear and Poisson regression models were conducted. The median BNP value was 18.6 pg/mL (interquartile range: 11.4-31.2 pg/mL). Participants in the first (≤2.19), second (2.19-3.27), an

SUBMITTER: Muroya T 

PROVIDER: S-EPMC12411227 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature