Prognostic impact of the timing of antihypertensive medication initiation for hypertension detected at health screening on primary prevention of adverse cardiovascular events: Age-stratified real-world data analysis.

ABSTRACT: The association between age and timing of antihypertensive treatment initiation and its effect on outcomes of patients with hypertension remain unclear. We investigated the impact of the time to antihypertensive therapy initiation for cardiovascular event primary prevention in an age-stratified analysis using data from a nationwide health claims database. This observational cohort study analyzed claim and health examination data recorded between January 1, 2005, and April 30, 2021, in the Japan Medical Data Center database. Patients with hypertension treated with antihypertensive agents were grouped by time (years) to therapy initiation: <1 (reference group), 1-2, and ≥2. The primary outcome was a composite outcome encompassing cardiovascular death, acute coronary syndrome, heart failure,

SUBMITTER: Ito H 

PROVIDER: S-EPMC12411247 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature