Brain Atrophy Can Predict the Severity and Prognosis of Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

ABSTRACT:

Background and purpose

Compare clinical and lab characteristics of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis cases with and without brain atrophy.

Methods

Assess cerebral atrophy using median temporal lobe atrophy (MTA) and global cortical atrophy (GCA) scores in 82 anti-NMDAR encephalitis cases.

Results

GCA (+) cases had higher proportions of status epilepticus (p<0.001), memory problems (p=0.031), sepsis (p<0.001), and mechanical ventilation need (p=0.001) than GCA (-) cases. MTA (+) cases had higher memory problems (p<0.001) and sepsis (p=0.002) than MTA (-) cases. GCA (+) and MTA (+) groups had higher max modified Rankin Scale (mRS) (p<0.001, p=0.002) and 1-year mRS (p<0.001, p

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12411291 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature