Reduction of carbonic anhydrase activity is associated with amelioration of obstructive sleep apnea.

ABSTRACT:

Background

The carbonic anhydrase (CA) enzyme plays an important role in the equilibration of carbon dioxide and bicarbonate (HCO₃) under the production of H⁺ ions. Emerging evidence suggest that CA activity may play a fundamental regulatory role on respiratory control mechanisms in obstructive sleep apnea (OSA). Clinical trials suggest that CA inhibitors significantly reduce OSA.

Methods

Data from three separate cohorts of healthy volunteers and patients with OSA were used to quantify CA activity in whole blood and cerebrospinal fluid (CSF). The influence of the CA inhibitory drugs acetazolamide and sulthiame, on CA activity in-vitro/in-vivo, was assessed. The association between CA-inhibitor plasma concentration and HCO₃, as well as the inf

SUBMITTER: Komai AM 

PROVIDER: S-EPMC12411314 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature