Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

ABSTRACT: Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related diseases. Therefore, telomeres are considered to be one of the biomarkers of aging, and increasing or maintaining telomere length may contribute to healthy aging and longevity. Epitalon has been the subject of several anti-aging studies however, quantitative data on the biomolecular pathway leading to telomere length increase, hTERT mRNA expression, telomerase enzyme activity, and ALT activation have not been extensively studied in different cell types. In this article, the breast cancer cell lines 21NT, BT474, and n

SUBMITTER: Al-Dulaimi S 

PROVIDER: S-EPMC12411320 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature