Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain-gut axis dysregulation.

ABSTRACT:

Introduction

Acute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and prognosis of AS.

Methods

In this study, we investigated alterations in gut microbiota composition and metabolomic profiles in AS patients using 16S rRNA sequencing and untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics technology.

Results

The results revealed significant changes in gut microbiota diversity and community structure in AS patients compared with healthy controls. Notably, the abundance of anti-inflammatory microbiota was increased significantly, accompanied by elevated levels of certai

SUBMITTER: Chen J 

PROVIDER: S-EPMC12411451 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature