Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome: can we use gut bacteria as potential biomarkers to characterize sepsis?

ABSTRACT:

Background

Critically ill patients, including those with systemic inflammatory response syndrome (SIRS) and sepsis, frequently exhibit gut microbiota disruption due to physiological stress and broad-spectrum antimicrobial therapy (AT). Although antibiotics are essential for controlling infection, they can destabilize the gut microbiota and may contribute to poorer clinical outcomes. The characterization of the gut microbiota of these patients may inform microbiota-based interventions to mitigate antibiotic-induced dysbiosis.

Objective

This study aimed to identify key bacterial taxa that distinguish sepsis from non-sepsis patients.

Methods

A total of 89 stool samples (51 non-sepsis, 38 sepsis) were evaluated by amplicon sequencing the 16S rRNA gene to assess microbiota

SUBMITTER: Ramalho Guerra R 

PROVIDER: S-EPMC12411461 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature