Combination of αCD4 antibody and retinal antigen injection induces long-term disease control in autoimmune uveitis.

ABSTRACT:

Introduction

Autoimmune uveitis is a sight-threatening inflammatory eye disease driven by immune dysregulation. We previously introduced a therapeutic strategy involving the in vivo induction of retinal-antigen-specific regulatory T cells (Tregs) via αCD4 antibody injection followed by administration of the retinal self-peptide IRBP1-20, which effectively suppresses inflammation during the onset of experimental autoimmune uveitis (EAU).

Methods

We evaluated the long-term therapeutic efficacy of this approach in a chronic EAU model. EAU was induced in C57BL/6 mice, and treatment was administered at each onset or relapse episode over a 28-week period. Disease progression was monitored by clinical scoring and funduscopy, with further assessment using histopathology and o

SUBMITTER: Qiao D 

PROVIDER: S-EPMC12411532 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature