Assessment of the role of probiotics in prevention of ventilator-associated pneumonia in neonates.

ABSTRACT:

Purpose

Ventilator-associated pneumonia (VAP) is a severe complication in NICUs. It increases morbidity, mortality, and healthcare costs. The research purpose was to evaluate the preventive value of probiotics on the incidence of VAP among ventilated neonates.

Methods

This prospective randomized controlled study was done at the NICU of Tanta University Hospitals for one year. Eighty full-term neonates who required invasive mechanical ventilation for over 48 h were randomly divided into a probiotic group (n = 40) and a non-probiotic group (n = 40). Besides the standard treatment that was given to both groups, the probiotic group received a sachet containing 1 × 10⁹ CFU of lactic acid bacteria twice a day, starting from the 1st day of recruitment until discharge. Ne

SUBMITTER: Khodair HA 

PROVIDER: S-EPMC12411592 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature