METTL1-driven epitranscriptomic enhancement of TXNDC12 boosts c-Myc stability through USP5 in HNSCC.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy worldwide. Advancing understanding of the molecular mechanisms driving tumor progression and resistance to therapy is essential for developing new strategies to improve patient outcomes in HNSCC. Here we demonstrate that elevated expression of thioredoxin domain-containing protein 12 (TXNDC12) in HNSCC is associated with adverse clinical outcomes and reduced survival. Modulating TXNDC12 levels demonstrates that its reduction curtails aggressive tumor phenotypes and cisplatin resistance, while its overexpression exacerbates these characteristics. Comprehensive RNA transcriptomic analysis reveals that depletion of TXNDC12 leads to significant suppression of c-Myc signaling pathways. Mechanistically, TXNDC12 stabilizes c-

SUBMITTER: Mai Z 

PROVIDER: S-EPMC12411639 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature