Targeting TRPV6/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone.

ABSTRACT: Bone metastasis most commonly occurs in castration-resistant prostate cancer (CRPC). The TRPV6 calcium channel is absent in healthy prostate tissue, but its expression increases considerably during cancer progression. We hypothesized that cancer cells induce TRPV6 expression de novo to directly benefit from tightly regulated calcium intake via TRPV6 while providing cancer cells with a selective advantage for metastasis in the calcium-abundant niche, such as bone. Using a cohort of prostate cancer tissue biopsies from patients with a clinical history of at least 10 years after biopsy, we report that TRPV6 expression directly correlates with CRPC tumor aggressiveness and increased risk of metastasis development. The TRPV6 channel is involved in the acquisition of both mesenchymal and invasiv

SUBMITTER: Cordier C 

PROVIDER: S-EPMC12411641 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature