Aspirin, Birthweight, and Large-For-Gestational-Age Neonates: A Secondary Analysis of the ASPRE Trial.

ABSTRACT:

Objective

To investigate the effects of aspirin on the distribution of birthweight and its impact on the rates of large-for-gestational-age (LGA) neonates.

Design

Secondary analysis of the Combined Multimarker Screening and Randomised Patient Treatment with Aspirin for Evidence-based Preeclampsia Prevention (ASPRE) trial.

Setting

Thirteen hospitals in England, Spain, Belgium, Greece, Italy and Israel.

Population

Participants of the ASPRE trial at increased risk of preterm pre-eclampsia (PE) who had a live birth.

Methods

We compared the birthweight distributions and the rates of LGA neonates between the trial groups. Analyses were stratified according to the presence of pre-existing diabetes mellitus and the development of PE, and logistic regression was

SUBMITTER: Rolnik DL 

PROVIDER: S-EPMC12411660 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature