Arjunolic Acid From Terminalia ivorensis A. Chev (Combretaceae) Possesses Anti-Breast Cancer Effects In Vitro and In Vivo.

ABSTRACT:

Background

Breast cancer is a major public health issue. In 2022, approximately 4,207 new cases and 2,285 deaths were reported in Cameroon. Given the limited accessibility and various issues associated with conventional treatments, herbal medicine has emerged as a promising alternative.

Aims

This study aimed to evaluate the potential anticancer activity of naturally occurring compounds isolated from Terminalia ivorensis A. Chev.

Methods and results

This was done by fractionating the methanolic extract of T. ivorensis and purifying the constituents obtained using conventional chromatographic techniques. Thereafter, the crude extract and its 5 isolates were subjected to in vitro MTT bioassay to assess their potential to kill human (MCF-7 and MDA-MB-231) and murine (4T1)

SUBMITTER: Akamse MA 

PROVIDER: S-EPMC12411669 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature