Peritoneal Lavage With Low GDP Neutral pH PD Solution Reduces Mortality and Severity in a Lethal Peritonitis Model.

ABSTRACT:

Introduction

The efficacy of peritoneal lavage monotherapy using PD solution for severe peritonitis remains unproven.

Methods

We evaluated the effects of 3-times and 6-times lavage using low GDP neutral PD solution on a Methicillin-sensitive Staphylococcus aureus (MSSA) lethal peritonitis model rats without antibiotic use. Changes in effluent viable bacteria numbers dependent on lavage frequency were determined in a further 10 rats.

Results

Compared to the lethal peritonitis model without lavage, both 3-times and 6-times lavage significantly reduced 24-h mortality, effluent FDP and creatinine concentrations. Furthermore, 6-times lavage significantly prevented the rough fur development, intraabdominal adhesion, and pus formation which developed in both the 0-times and

SUBMITTER: Ikeda M 

PROVIDER: S-EPMC12411685 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature