Association of first-trimester exposure to Kampo medicines containing <i>Prunus persica</i> kernel with preterm birth and major congenital malformations: a Japanese database study.

ABSTRACT:

Introduction

Traditional Japanese (Kampo) medicine containing Prunus persica kernel (KPK) is prescribed for treating menstrual- and pregnancy-related symptoms. However, no safety information is available regarding its use in pregnant women. In this study, we examined the associations of KPK prescriptions during the first trimester of pregnancy with preterm births and major congenital malformations (MCMs) in newborns.

Methods

From a large-scale Japanese health insurance claims database, we included pregnant women enrolled with the same healthcare insurer from 3 months before pregnancy to the date of delivery, who gave birth between 2010 and 2019, and whose data were linked to their infants. We then selected pregnant women who were prescribed KPK during the first trimes

SUBMITTER: Suzuki S 

PROVIDER: S-EPMC12411776 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature