Enhanced identification of <i>Morganella</i> spp. using MALDI-TOF mass spectrometry.

ABSTRACT:

Introduction

The genus Morganella, including clinically isolated species M. sibonii and M. morganii, has a still underexplored role in clinical microbiology. Despite the clinical relevance of Morganella spp., current MALDI-TOF commercial systems fail to differentiate these species. Whole genome sequencing (WGS) remains the most effective method to distinguish species. However, this method is not adapted for routine lab workflow. Enhancing MALDI-TOF's accuracy could make it a rapid and effective approach for distinguishing Morganella species in routine laboratory diagnostics.

Objectives

This study aims to improve the performance of MALDI-TOF for identifying Morganella spp. using WGS as the gold-standard reference method.

Methods

SUBMITTER: Duque M 

PROVIDER: S-EPMC12411857 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature