Natural product Erianin: mitigating FOLFOX toxicity and enhancing against colorectal cancer.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is a prevalent malignant tumor of the digestive tract. The FOLFOX regimen (oxaliplatin + calcium folinate + 5-fluorouracil) serves as the primary treatment for advanced CRC clinically, yet its application is significantly limited by substantial toxic side effects. Erianin, a natural compound from Chinese medicine Dendrobium chrysotoxum Lindl, demonstrates significant potential in both tumor growth inhibition and chemotherapy toxicity reduction. This study aims to investigate the potential of Erianin in reducing the toxicity of the FOLFOX regimen while enhancing its antitumor efficacy.

Methods

This study integrated network toxicology and molecular docking to predict the potential targets of Erianin in alleviating FOLFOX-induced side

SUBMITTER: Yang F 

PROVIDER: S-EPMC12411860 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature