Granger causality connectivity analysis of persistent atrial fibrillation dynamics reveals posterior wall mechanistic insights.

ABSTRACT:

Background

Adjunctive posterior wall isolation (PWI) to pulmonary vein isolation (PVI) has not demonstrated convincing benefit during atrial fibrillation (AF) ablation. To provide mechanistic insight for null PWI trials, we undertook Granger causality (GC) analysis of noncontact left atrial (LA) electroanatomic maps.

Objective

This study aimed to apply GC to intracardiac electrograms to uncover patient-specific AF dynamics and describe a proof-of-concept approach to targeted PWI after PVI.

Methods

A prospective cohort study was undertaken at Royal Brompton Hospital. Consecutive patients undergoing PVI with noncontact mapping (AcQmap; Acutus Medical) before and after PVI were included.

Results

In 21 patients, causality pairing index, a GC measure of organization

SUBMITTER: Barker J 

PROVIDER: S-EPMC12411957 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature