Organic AIE Nanoradiosensitizer Potentiates X-Ray Triggered Continuous Reactive Oxygen Species Generation for Potent Cancer Radioimmunotherapy.

ABSTRACT: Organic radiosensitizers (ORSs), with structural versatility, hold promise for sensitizing radiotherapy (RT) by interacting with X-ray photons to generate reactive oxygen species (ROS). They often consist of low-Z elements that have inherently low X-ray deposition capability. However, current ORSs suffer from short circulation half-lives and low tumor retention, contradicting their requirements for sustained ROS generation upon RT in tumor sites. Herein, a glutathione-responsive system is prepared, loaded with aggregation-induced emission molecules (TPEPy-I) and Ferriprotoporphyrin IX chloride (Hemin), to act as an ORS (named THN) for X-ray triggered sustained ROS generation for efficient antitumor immunotherapy. In detail, THN effectively deposited X-ray photons, which interact with water

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12411993 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature